Molecular biology of the gene / James D. Watson, Tania A. Baker, Alexander Gann, Michael Levine, Berkeley, Richard Losik,

Includes bibliographical references and index.

I. HISTORY

1. Mendelian View of the World

2. Nucleic Acids Convey Genetic Information



II. STRUCTURE AND STUDY OF MACROMOLECULES

3. Weak and strong chemical bonds.

4. The Structure of DNA

5. The Structure of RNA

6. The Structure of Proteins and Protein: Nucleic Acid Interactions

7. Techniques of Molecular Biology



III. MAINTENANCE OF THE GENOME

8. Genome Structure, Chromatin and the Nucleosome

9. The Replication of DNA

10. The Mutability and Repair of DNA

11. Homologous Recombination at the Molecular Level

12. Site Specific Recombination and Transposition of DNA



IV. EXPRESSION OF THE GENOME

13. Mechanisms of Transcription

14. RNA Splicing

15. Translation

16. The Genetic Code

17. Origins and early evolution of life



V. REGULATION

18. Transcriptional Regulation in Prokaryotes

19. Transcriptional Regulation in Eukaryotes

20. Regulatory RNAs

21. Gene Regulation in Development and Evolution

22. Systems Biology



APPENDIX:

Model Organisms

Now completely up-to-date with the latest research advances, the Seventh Edition of James D. Watson’s classic book, Molecular Biology of the Gene retains the distinctive character of earlier editions that has made it the most widely used book in molecular biology. Twenty-two concise chapters, co-authored by six highly distinguished biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.

Features
Balanced coverage of prokaryotic and eukaryotic systems is included.
To support the concise narrative, additional material can be found in essay boxes that are labeled in four categories:
Key or Classic Experiments highlight influential experimental strategies that show students how we know what we know.
Techniques include recent methods from the fields of bioinformatics and genomics.
Advanced Concepts provide further discussions of key theories and principles.
Medical Connections highlight how understanding basic mechanisms sheds light on—and may lead to treatment of—medical conditions and human diseases.
New to this Edition
Highlights of Changes to the Book:

A new section early in the book, entitled “The Structure and Study of Macromolecules”, builds from the concepts of basic chemical bonds in simple molecules to the formation of macromolecules and includes two new chapters, “The Structure of RNA” and “The Structure of Proteins and Protein: Nucleic acid interactions”. The chapters in this section provide a coherent and comprehensive description ofthe structures of DNA, RNA and proteins, and their various interactions, as well as the strategies and techniques used to study them.
A new chapter on the Origins and Early Evolution of Life shows how the techniques of molecular biology and biochemistry allow us to consider—even reconstruct—how life might have arisen, and addresses the prospect of creating life in a test tube. The chapter also demonstrates how, even at the very early stages of life, molecular processes were subject to evolution. This chapter reinforces many basic principles of chemistry and molecular biology in a new context, helping the student appreciate them more fully
A more complete integration of experiments and methods is woven into the text. A newly revised chapter on basic, as well as advanced, methods of molecular biology and genomics is presented early in the book, before students learn about the details and processes of molecular biology—replication, recombination, gene expression. More specialized techniques, tied to those particular processes, are included within boxes in the relevant chapters.
Improved summaries at the end of each chapter focus on the key concepts covered.
New End-of-chapter problems provide students with opportunities to practice responding to the kinds of short-answer or essay questions that they might see on a test or exam. An answer key for the odd-numbered questions is provided in an Appendix®.