Computer-Aided Analysis of Fluorescein Angiograms Using Color Leakage Maps / (Record no. 8797)

MARC details
000 -LEADER
fixed length control field 11510nam a22002537a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210111b2013 a|||f mb|| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-CaNU
Transcribing agency EG-CaNU
041 0# - Language Code
Language code of text eng
Language code of abstract eng
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number 610
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Eman Magdy Ahmed
245 1# - TITLE STATEMENT
Title Computer-Aided Analysis of Fluorescein Angiograms Using Color Leakage Maps /
Statement of responsibility, etc. Eman Magdy Ahmed
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2013
300 ## - PHYSICAL DESCRIPTION
Extent 104 p.
Other physical details ill.
Dimensions 21 cm.
500 ## - GENERAL NOTE
Materials specified Supervisor: Ahmed Fahmy
502 ## - Dissertation Note
Dissertation type Thesis (M.A.)—Nile University, Egypt, 2013 .
504 ## - Bibliography
Bibliography "Includes bibliographical references"
505 0# - Contents
Formatted contents note Contents:<br/>Chapter 1: INTRODUCTION ..................................................................................................... 1<br/>1.1 Objectives ..................................................................................................................... 1<br/>1.2 Motivation ..................................................................................................................... 2<br/>1.3 Research Flow ............................................................................................................... 2<br/>1.4 Datasets ......................................................................................................................... 3<br/>1.5 Organization of thesis ................................................................................................... 4<br/>Chapter 2: BACKGROUND ........................................................................................................ 5<br/>2.1 Anatomy of Human Eye ............................................................................................... 5<br/>2.1.1 Retina ................................................................................................................ 7<br/>2.2 Retinal imaging ........................................................................................................... 10<br/>2.2.1 Fundus Fluorescein Angiography ...................................................................... 10<br/>2.2.1.1 Normal Fluorescein Angiograms ........................................................ 11<br/>2.2.1.2 Abnormal Fluorescein Angiograms .................................................... 13<br/>2.2.2 Optical Coherence Tomography ........................................................................ 16<br/>2.2.2.1 Normal Optical Coherence Tomograms ............................................. 17<br/>2.2.2.2 Abnormal Optical Coherence Tomograms ......................................... 18<br/>2.3 Retinal Diseases .......................................................................................................... 19<br/>2.3.1 Diabetic Macular Edema.................................................................................... 19<br/>2.3.2 Age-related Macular Degeneration .................................................................... 21<br/>2.4 Summary ..................................................................................................................... 25<br/>Chapter 3: IMAGE PRE-PROCESSING ................................................................................. 27<br/>3.1 Image Registration ......................................................................................................<br/>3.1.1 Literature Review............................................................................................ 27<br/>3.1.2 Methodology ................................................................................................... 29<br/>3.1.3 Implementation ............................................................................................... 31<br/>3.1.4 Experiments .................................................................................................... 32<br/>3.2 Vessel Removal .......................................................................................................... 33<br/>3.2.1 Literature Review............................................................................................ 33<br/>3.2.2 Methodology ................................................................................................... 33<br/>3.2.3 Implementation ............................................................................................... 35<br/>3.2.4 Experiments .................................................................................................... 37<br/>3.3 Macula Cropping ........................................................................................................ 38<br/>3.3.1 Methodology ................................................................................................... 38<br/>3.3.2 Implementation ............................................................................................... 38<br/>3.3.3 Experiments .................................................................................................... 39<br/>3.4 Intensity Normalization .............................................................................................. 40<br/>3.4.1 Methodology ................................................................................................... 40<br/>3.4.2 Implementation ............................................................................................... 40<br/>3.4.3 Experiments .................................................................................................... 41<br/>3.5 Summary ..................................................................................................................... 42<br/>Chapter 4: LESION ENHANCEMENT ................................................................................... 43<br/>4.1 Modeling the Early Macula ........................................................................................ 43<br/>4.1.1 Literature Review............................................................................................ 44<br/>4.1.2 Methodology ................................................................................................... 45<br/>4.1.3 Implementation ............................................................................................... 46<br/>4.1.4 Experiments .................................................................................................... 48<br/>4.2 Subtraction .................................................................................................................. 49<br/>4.2.1 Methodology ................................................................................................... 49<br/>4.2.2 Implementation ............................................................................................... 49<br/>4.2.3 Experiments .................................................................................................... 50<br/>4.3 Summary ..................................................................................................................... 52<br/>Chapter 5: COLOR MAPPING ................................................................................................ 53<br/>5.1 Simulating OCT line scans (Re-sampling) .................................................................<br/>5.1.1 Methodology ................................................................................................... 54<br/>5.1.2 Implementation ............................................................................................... 54<br/>5.1.3 Experiments .................................................................................................... 54<br/>5.2 Simulating OCT image reconstruction ....................................................................... 55<br/>5.2.1 Methodology ................................................................................................... 55<br/>5.2.2 Implementation ............................................................................................... 56<br/>5.2.3 Experiments .................................................................................................... 58<br/>5.3 Mapping ...................................................................................................................... 59<br/>5.3.1 Methodology ................................................................................................... 59<br/>5.3.2 Implementation ............................................................................................... 60<br/>5.3.3 Experiments .................................................................................................... 62<br/>5.4 Summary ..................................................................................................................... 65<br/>Chapter 6: RESULTS AND EVALUATION ........................................................................... 67<br/>6.1 Results ......................................................................................................................... 67<br/>6.2 Evaluation ................................................................................................................... 69<br/>6.2.1 Correlation between FLM and OCT ............................................................... 69<br/>6.2.2 Reproducibility of FLM .................................................................................. 72<br/>Chapter 7: CONCLUSION AND FUTURE WORK ............................................................... 75<br/>7.1 Conclusion .................................................................................................................. 75<br/>7.2 Future Work ................................................................................................................
520 3# - Abstract
Abstract Abstract:<br/>Fundus Fluorescein Angiography (FFA) is a standard screening and diagnostic technique for several retinal diseases. FFA is powerful and essential for detecting and treatment-guiding of vascular-related retinal diseases such as diabetic retinopathy, macular edema, macular degeneration, retinal detachment, vascular occlusion, and tumors. Nevertheless, current analysis methods of FFA images depend on subjective evaluation of the amount of fluorescein leakage. This evaluation is qualitatively performed by skilled observers. Accordingly, these methods are vulnerable to inter-/intra-observer variability and lack accuracy and reproducibility as well.<br/>In this thesis, we present a new method for computer-aided analysis of FFA images. The method is based on generating objective color fluorescein leakage maps (FLM) that mimic the thickness maps produced by Optical Coherence Tomography (OCT). The generated FLM evaluates the fluorescein leakage and gives an indication about its severity. A complete system is introduced in this work to automatically generate FLM. It starts with pre-processing steps including: image registration, retinal blood vessels removal, cropping the macula and normalizing intensity between images. Then, modeling the early macula timeframes before subtracting it from late timeframes has been followed. Finally, simulating OCT image reconstruction has been presented to generate color FLMs. The proposed method was applied to 64 datasets of two different retinal diseases and the FLMs results were compared to the OCT thickness maps. The results show strong correlation between the FLMs and OCT thickness maps (r=0.8). The proposed method was found to be reproducible and robust to variability in the image acquisition times.
546 ## - Language Note
Language Note Text in English, abstracts in English.
650 #4 - Subject
Subject Informatics-IFM
655 #7 - Index Term-Genre/Form
Source of term NULIB
focus term Dissertation, Academic
690 ## - Subject
School Informatics-IFM
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
650 #4 - Subject
-- 266
655 #7 - Index Term-Genre/Form
-- 187
690 ## - Subject
-- 266
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Home library Current library Date acquired Total Checkouts Full call number Date last seen Price effective from Koha item type
    Dewey Decimal Classification   Not For Loan Main library Main library 01/11/2021   610 / EA.C 2013 01/11/2021 01/11/2021 Thesis